Como, 5-th May, 2023. Ontonix Publishes Article in Biomedical Journal of Science and Technology on “Protein Folding – Quantification of Protein Complexity, Robustness and Amino Acid Participation”. The QCT (Quantitative Complexity Theory) algorithm has been applied to the analysis of the folding process of a protein composed of 435 atoms, monitoring its complexity at each step thereof. The folding has been simulated using Molecular Dynamics Simulation. The analysis has revealed that, while in the native state, the protein’s configuration minimizes its energy, its complexity reaches a maximum.
The experiment described in the paper illustrates how complexity can be used to measure the robustness of a protein, which may be linked to its longevity, as well as determine teh degree of participation of each amino acid in the protein’s global properties.
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Biomedical Journal of Scientific & Technical Research (BJSTR –www.biomedres.us) is a multidisciplinary, scholarly Open Access publisher focused on Genetic, Biomedical and Remedial missions in relation with Technical Knowledge as well.
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